14.3.3 beta protein (30R-1163)
Purified recombinant Human 14.3.3 beta protein
|Synonyms||Protein kinase C inhibitor protein 1 protein, Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein Beta Polypeptide., Brain protein 14 3 3 beta isoform protein, HS1 protein, 14-3-3 beta, 14-3-3 beta protein, beta polypeptide protein, KCIP-1 protein, GW 128 protein, Protein 1054 protein, YWHAB protein, 14.3.3 beta, HS 1 protein, 14/3/3 beta protein, beta polypeptide 14 3 3 protein beta/alpha protein, GW128 protein, 14-3-3 beta protein, KCIP 1 protein, Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein protein, Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein protein, KCIP1 protein, 14/3/3 beta|
Coomassie Blue stained SDS-PAGE of 14.3.3 beta protein (30R-1163)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-246 amino acids: MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN|
|Grade & Purity||> 90% pure|
|Molecular Weight||28 kDa (246 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 1mM EDTA, and 50mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human 14-3-3 beta was expressed in E. coli and purified by using conventional chromatography techniques.|
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