Activin A protein (30R-AA005)

Purified recombinant Human Activin A protein

Synonyms Activin beta-A protein, Inhibin beta-A protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Activin protein corresponding to amino acids GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS.
Expression System Hi-5 cells
Grade & Purity > 95% pure
Molecular Weight 26 kDa
Form & Buffer Lyophilized from 10 mM Citric Acid pH 3.0. Reconstitute in water to a concentration of 0.5 mg/ml. Do not vortex.

Usage & Assay Information

Bioactivity The ED50 as determined by its ability to inhibit the proliferation of Mouse MPC-11 cells is 2 ng/ml, corresponding to a specific activity of 5 x 10^5 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Activin A is a TGF beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF beta antagonist, Follistatin.

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Availability: In stock

Price: £180.28
Size: 5 ug
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