ADD3 antibody (70R-9941)
Affinity purified rabbit polyclonal ADD3 antibody
|Synonyms||Polyclonal ADD3 antibody, Anti-ADD3 antibody, gamma antibody, ADD 3, ADDL antibody, adducin 3, ADD-3, ADD-3 antibody, ADD3, ADD 3 antibody|
|Immunogen||ADD3 antibody was raised in rabbit using the middle region of ADD3 as the immunogen|
|Assay Information||ADD3 Blocking Peptide, catalog no. 33R-1637, is also available for use as a blocking control in assays to test for specificity of this ADD3 antibody|
Western Blot analysis using ADD3 antibody (70R-9941)
ADD3 antibody (70R-9941) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.sPolymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains.|
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