ADSL antibody (70R-9952)
Affinity purified rabbit polyclonal ADSL antibody
|Synonyms||Polyclonal ADSL antibody, Anti-ADSL antibody, AMPS antibody, ASASE antibody, ASL antibody, adenylosuccinate lyase antibody|
|Immunogen||ADSL antibody was raised in rabbit using the middle region of ADSL as the immunogen|
|Assay Information||ADSL Blocking Peptide, catalog no. 33R-8172, is also available for use as a blocking control in assays to test for specificity of this ADSL antibody|
Western Blot analysis using ADSL antibody (70R-9952)
ADSL antibody (70R-9952) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.|
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