ALDH5A1 protein (His tag) (80R-1485)
Purified recombinant Human ALDH5A1 protein
|Synonyms||SSADH protein, ALDH5A1, ALDHA1-5, ALDHA1-5 protein, ALDHA1 5, SSDH protein, mitochondrial, ALDHA1 5 protein, Succinate-semialdehyde dehydrogenase protein|
Coomassie Blue stained SDS-PAGE of ALDH5A1 protein (His tag) (80R-1485)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||48-535 amino acids: MGSSHHHHHH SSGLVPRGSH MAGRLAGLSA ALLRTDSFVG GRWLPAAATF PVQDPASGAA LGMVADCGVR EARAAVRAAY EAFCRWREVS AKERSSLLRK WYNLMIQNKD DLARIITAES GKPLKEAHGE ILYSAFFLEW FSEEARRVYG DIIHTPAKDR RALVLKQPIG VAAVITPWNF PSAMITRKVG AALAAGCTVV VKPAEDTPFS ALALAELASQ AGIPSGVYNV IPCSRKNAKE VGEAICTDPL VSKISFTGST TTGKILLHHA ANSVKRVSME LGGLAPFIVF DSANVDQAVA GAMASKFRNT GQTCVCSNQF LVQRGIHDAF VKAFAEAMKK NLRVGNGFEE GTTQGPLINE KAVEKVEKQV NDAVSKGATV VTGGKRHQLG KNFFEPTLLC NVTQDMLCTH EETFGPLAPV IKFDTEEEAI AIANAADVGL AGYFYSQDPA QIWRVAEQLE VGMVGVNEGL ISSVECPFGG VKQSGLGREG SKYGIDEYLE LKYVCYGGL|
|Grade & Purity||> 90% pure|
|Molecular Weight||54.6 kDa (509aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT, 0.1M NaCl and 1mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mediator of the NADP+-dependent oxidation of aldehydes into acids and plays an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH5A1 is expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta. Recombinant human ALDH5A1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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