alpha Synuclein protein (30R-1000)

Purified recombinant Human alpha Synuclein protein

Synonyms PARK1 protein, NACP protein, MGC127560 protein, PARK 4 protein, alpha-Synuclein protein, PD1 protein, Non-A beta component of AD amyloid protein, alphaSYN protein, Non-A4 component of amyloid precursor protein, MGC105443 protein, PD 1 protein, MGC64356 protein, Non A4 component of amyloid precursor protein, SNCA protein, Synuclein alpha protein, MGC110988 protein, Parkinson disease familial 1 protein, Non-A-beta component of alzheimers disease amyloid protein, , PARK4 protein, Non A beta component of AD amyloid protein, precursor of PARK 1 protein, Alpha-synuclein isoform NACP140 protein, Alpha synuclein protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of alpha Synuclein protein (30R-1000)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 14.4 kDa (140 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
Form & Buffer Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl, and 1mM MgCl2.
Concentration 1 mg/ml

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Endotoxin Levels < 1.0 EU per ug of protein (determined by LAL method)

General Information

Biological Significance alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson?s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).

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Images

  • Coomassie Blue stained SDS-PAGE of alpha Synuclein protein (30R-1000) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: £200.31
Size: 100 ug
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