APP antibody (20R-AG005)

Goat polyclonal APP antibody

Synonyms Polyclonal APP antibody, Anti-APP antibody, Amyloid Precursor Protein antibody
Specificity Human APP
Cross Reactivity To be determined by end-user
Applications ELISA, WB
Immunogen APP antibody was raised in goat using a peptide; GYENPTYKFFEQMQN, as the immunogen.

Specifications

Host Goat
Form & Buffer Supplied as liquid neat serum without preservative.

Usage & Assay Information

Usage Recommendations ELISA: >1:5,000, WB: >1:25,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The amyloid precursor protein (APP) is a large membrane protein whose C-terminus projects into the extracellular space. In Alzheimer's disease (AD), the APP is proteolytically cleaved at the N-terminal of Ab by b-secretase (BACE) to release a ~100 kDa APPsb protein into the extracellular space. The remaining 12 kDa fragment remains membrane bound where it can be cleaved at its C-terminus by g-secretase (presenilins) to release the insoluble Ab peptide into the extracellular space with the ~8 kDa APP C-terminal fragment (CTFb) remaining membrane bound. The APP is the subject of intensive investigations to determine how this protein is broken down abnormally in AD brains to give rise to Ab, which is present in senile plaques and vessels.

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Availability: In stock

Price: £120.19
Size: 250 ul
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