AURKB antibody (10R-1182)

Mouse monoclonal AURKB antibody

Synonyms Monoclonal AURKB antibody, Anti-AURKB antibody, Serine/threonine-protein kinase 12 antibody, AURKB antibody, Aurora 1 antibody, AurB antibody, STK1 antibody, Aurora-B antibody, Aurora related kinase 2 antibody, Aurora/IPL1 related kinase 2 antibody, aurkb-sv1 antibody, STK12 antibody, Serine/theronine kinase 12 antibody, AIM1 antibody, aurkb antibody, Aurora kinase B antibody, Serine/threonine protein kinase 12 antibody, AIM1 antibody, aurkb-sv2 antibody, ARK2 antibody, IPL1 antibody, AIK2 antibody, STK5 antibody, Aurora and Ipl1 like midbody associated protein 1 antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, IF
Immunogen AURKB antibody was raised in mouse using recombinant human Aurora kinase B (1-344aa) purified from E. Coli as the immunogen.

Images

Immunofluorescent staining using for AURKB antibody (10R-1182)

Immunofluorescenitrocellulosee of human HeLa cells stained with Hoechst 3342 (Blue) for chromatin staining and monoclonal anti-human Aurora kinase B antibody (1:2000) with Texas Red (Red).

Specifications

Host Mouse
Clone AT2B1
Isotype IgG2b kappa
Source Anti-human Aurora kinase B antibody, clone AT2B1, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Aurora kinase B protein.
Method of Purification AURKB antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations IF: 1:1,000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells

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Images

  • Immunofluorescent staining using for AURKB antibody (10R-1182) | Immunofluorescenitrocellulosee of human HeLa cells stained with Hoechst 3342 (Blue) for chromatin staining and monoclonal anti-human Aurora kinase B antibody (1:2000) with Texas Red (Red).

Availability: In stock

Price: £212.33
Size: 100 ul
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