BAG1 protein (30R-1508)
Purified recombinant Human BAG1 protein
|Synonyms||BAG-1 protein, BCL 2 binding athanogene 1 protein, BCL 2 Associated Athanogene 1 protein, BAG1, BAG 1 protein, HAP1 protein, BCL2-associated athanogene 1 Bag 1 protein, HAP protein, Glucocorticoid receptor-associated protein RAP46 protein, BCL2 associated athanogene protein, Haptoglobin protein, BAG-1, BCL 2 associated athanogene protein, BCL2 associated athanogene 1 protein, RAP 46., RAP46 protein, BAG 1, BAG family molecular chaperone regulator 1 protein|
Coomassie Blue stained SDS-PAGE of BAG1 protein (30R-1508)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-230 amino acids: MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV QAFLAECDTV EQNICQETER LQSTNFALAE|
|Grade & Purity||> 90% pure|
|Molecular Weight||25.9 kDa (230aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 100mM NaCl and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||BCL2-associated athanogene, also known as BAG1, is a member of the Bcl-2 family of proteins that play varied stimulatory or inhibitory roles in the regulation of programmed cell death. This functions in conjunction with Bcl-2 to inhibit apoptosis. Also, BAG1 has been implicated in age related neurodegenerative diseases as Alzheimer's. It is localized to the cytosol, nucleus or both. Recombinant human BAG1 was expressed in E. coli and purified by using conventional chromatography techniques.|
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