BAG2 antibody (70R-1666)

Rabbit polyclonal BAG2 antibody raised against the C terminal of BAG2

Synonyms Polyclonal BAG2 antibody, Anti-BAG2 antibody, RP3-496N17.2 antibody, MGC149462 antibody, Bcl2-Associated Athanogene 2 antibody, dJ417I1.2 antibody, BAG-2 antibody, KIAA0576 antibody
Specificity BAG2 antibody was raised against the C terminal of BAG2
Cross Reactivity Human, Mouse, Rat, Dog, ZebraFish
Applications IHC, WB
Immunogen BAG2 antibody was raised using the C terminal of BAG2 corresponding to a region with amino acids VDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSK
Assay Information BAG2 Blocking Peptide, catalog no. 33R-9474, is also available for use as a blocking control in assays to test for specificity of this BAG2 antibody

Images

Immunohistochemical staining using BAG2 antibody (70R-1666)

BAG2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X

Specifications

Host Rabbit
Method of Purification Total IgG Protein A purified
Molecular Weight 23 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 100ul distilled water for a 1mg/ml concentration of BAG2 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1.25 ug/ml; IHC: 4-8 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

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Images

  • Immunohistochemical staining using BAG2 antibody (70R-1666) | BAG2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X
  • Western Blot analysis using BAG2 antibody (70R-1666) | BAG2 antibody (70R-1666) used at 1.25 ug/ml to detect target protein.

Availability: In stock

Price: £220.34
Size: 100 ug
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