beta 2 Microglobulin protein (His tag) (80R-1386)
Purified recombinant Human B2M protein
|Synonyms||CDABP0092 protein, beta Microglobulin 2, Beta-2-microglobulin protein, HDCMA22P, beta Microglobulin-2 protein, beta 2 Microglobulin, beta Microglobulin-2, B2M protein, beta Microglobulin 2 protein|
Coomassie Blue stained SDS-PAGE of beta 2 Microglobulin protein (His tag) (80R-1386)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||21-119 amino acids: MGSSHHHHHH SSGLVPRGSH MIQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM|
|Grade & Purity||> 95% pure|
|Molecular Weight||14.0 kDa (120aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 2mM DTT and 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Beta 2 microglobulin, also known as B2M, is a component of MHC class I molecules, Involved in the presentation of peptide proteins to the immune system. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. This increase is seen in people with cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma. Multiple myeloma is a malignancy (cancer) of a certain kind of white blood cell, called a plasma cell. B2M Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease. Recombinant B2M protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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