BMP4 protein (30R-1255)
Purified recombinant Human BMP4 protein
|Synonyms||Bone morphogenetic protein 4 BMP 4 protein, BMP 4 protein, DVR4 protein, BMP 4, BMP-4 protein, BMP-4, BMP-2B protein, BMP4, ZYME., BMP2B1 protein, BMP2B protein|
Coomassie Blue stained SDS-PAGE of BMP4 protein (30R-1255)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||293-408 amino acids: MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR|
|Grade & Purity||> 95% pure|
|Molecular Weight||13.2 kDa (117 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 10mM sodium citrate buffer, pH 3.5, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF-beta superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva. Recombinant BMP-4 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.|
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