BMP7 protein (His tag) (80R-1107)
Purified recombinant Human BMP7 protein
|Synonyms||OP-1 protein, BMP 7 protein, BMP-7 protein, Osteogenic protein1 protein, BMP-7, Bone morphogenetic protein 7 BMP 7 protein, Eptotermin alfa protein, BMP 7, BMP7, OP 1 protein, OP1.|
Coomassie Blue stained SDS-PAGE of BMP7 protein (His tag) (80R-1107)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||293-431 amino acids: MSTGSKQRSQ NRSKTPKNQE ALRMANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH LEHHHHHH|
|Grade & Purity||> 95% pure|
|Molecular Weight||16.8 kDa (148 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 10mM sodium citrate buffer, pH 3.5, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Bone morphogenic protein-7 (BMP-7/OP-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. Like other members of the BMPs family, it plays a role in calcium regulation and bone homeostasis. BMPs have been also shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP7 also has the potential for treatment of chronic kidney disease. Recombinant human BMP-7 protein was expressed in E. coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.|
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