Calbindin 1 protein (30R-1381)
Purified recombinant Human Calbindin 1 protein
|Synonyms||Calbindin -1 protein, Calbindin 1 protein, Calbindin -1, Calbindin 1, CAB27 protein, , D-28K protein, Calbindin1 protein, calbindin 1 28kDa protein, Calbindin D28 protein, CALB1 protein, CALB protein, Calbindin 1|
Coomassie Blue stained SDS-PAGE of Calbindin1 protein (30R-1381)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-261 amino acids: MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT DLALILCAGD N|
|Grade & Purity||> 95% pure|
|Molecular Weight||30 kDa (261aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 10% glycerol, and 2mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Calbindin 1 is a calcium binding protein belonging to the troponin C superfamily. Calbindin is expressed in neural tissues. It plays an essential role in calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to epilepsy, amyotrophic lateral sclerosis, Huntington's disease. Recombinant human Calbindin1 was expressed in E. coli and purified by using conventional chromatography techniques.|
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