Casein Kinase 1 alpha antibody (10R-1146)

Mouse monoclonal Casein Kinase 1 alpha antibody

Synonyms Monoclonal Casein Kinase 1 alpha antibody , Anti-Casein Kinase 1 alpha antibody, Casein Kinase 1 alpha antibody, Casein Kinase 1 alpha, antibody, CK1 antibody, - antibody,
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen Casein Kinase 1 alpha antibody was raised in mouse using recombinant human Casein Kinase 1 alpha (1-337aa) purified from E. coli as the immunogen.

Images

Western Blot analysis of Casein Kinase 1 alpha antibody (10R-1146)

Cell lysates of HeLa and MCF7 (40 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human Casein Kinase 1 alpha (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Host Mouse
Clone AT2E2
Isotype IgG2b kappa
Source Anti-human Casein Kinase 1 alpha antibody, clone AT2E2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Casein Kinase 1 alpha protein.
Method of Purification Casein Kinase 1 alpha antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1,000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Caseine Kinase 1 alpha belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Perhaps it can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. Caseine kinase 1 alpha also interacts with the Axin complex

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Images

  • Western Blot analysis of Casein Kinase 1 alpha antibody  (10R-1146) | Cell lysates of HeLa and MCF7 (40 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human Casein Kinase 1 alpha (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Availability: In stock

Price: £212.33
Size: 100 ul
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