CBR1 protein (30R-1311)
Purified recombinant Human CBR1 protein
|Synonyms||Carbonyl reductase 1 15 hydroxyprostaglandin dehydrogenase [NADP+] protein, CBR1 protein, CBR 1, Carbonyl reductase [NADPH] 1.CBR 1 protein, CBR protein, hCBR1 protein, SDR21C1 protein, Prostaglandin E(2) 9 reductase., NADPH dependent carbonyl reductase 1 protein, CBR-1, CRN protein, Carbonyl reductase 1 protein, CBR1, Prostaglandin 9 ketoreductase protein, CBR 1 protein, CBR-1 protein|
Coomassie Blue stained SDS-PAGE of CBR1 protein (30R-1311)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-277 amino acids: MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW|
|Grade & Purity||> 95% pure|
|Molecular Weight||30 kDa (277aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.5, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CBR1 (Carbonyl reductase 1) is one of several monomeric NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. CBR1 is widely distributed in human tissues. CBR1 metabolizes many toxic environmental quinones and pharmacologically relevant substrates such as the anticancer doxorubicin. CBR1 can also convert prostaglandin E2 to prostaglandin F2-alpha. Recombinant human CBR1 protein was expressed in E. coli and purified by using conventional chromatography.|
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