CBX1 protein (His tag) (80R-1871)
Purified recombinant CBX1 protein
|Synonyms||HP1Hs-beta protein, CBX1, CBX 1 protein, CBX-1, CBX-1 protein, HP1Hsbeta protein, CBX protein, CBX 1, p25beta protein, HP1-BETA protein, MOD1 protein, M31 protein|
Coomassie Blue stained SDS-PAGE of CBX1 protein (His tag) (80R-1871)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-185 amino acids: MGSSHHHHHH SSGLVPRGSH MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN TWEPEENLDC PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP KKKKEESEKP RGFARGLEPE RIIGATDSSG ELMFLMKWKN SDEADLVPAK EANVKCPQVV ISFYEERLTW HSYPSEDDDK KDDKN|
|Grade & Purity||> 85% pure|
|Molecular Weight||23.6 kDa (205aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 2mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CBX1 is a member of the heterochromatin protein family, enriched in the heterochromatin and associated with centromeres. It is recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. This protein may play an important role in the epigenetic control of chromatin structure and gene expression. Recombinant human CBX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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