CD22 antibody (70R-9914)
Affinity purified rabbit polyclonal CD22 antibody
|Synonyms||Polyclonal CD22 antibody, Anti-CD22 antibody, CD 22 antibody, CD-22, CD 22, SIGLEC-2 antibody, CD22 molecule antibody, FLJ22814 antibody, CD-22 antibody, SIGLEC2 antibody, MGC130020 antibody, CD22|
|Immunogen||CD22 antibody was raised in rabbit using the N terminal of CD22 as the immunogen|
|Assay Information||CD22 Blocking Peptide, catalog no. 33R-9398, is also available for use as a blocking control in assays to test for specificity of this CD22 antibody|
Western Blot analysis using CD22 antibody (70R-9914)
CD22 antibody (70R-9914) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins; one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.|
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