CD5 antibody (10R-CD5bMS)

Rat monoclonal CD5 antibody

Synonyms Monoclonal CD5 antibody, Anti-CD5 antibody, Ly1 antibody, CD5, CD-5 antibody, CD 5, CD 5 antibody, CD-5
Specificity Murine
Applications FC
Immunogen CD5 antibody was raised in rat using CD5/Lyt-1 as the immunogen.

Specifications

Host Rat
Clone 4H8E6
Isotype IgG2a
Form & Buffer Supplied as a liquid in 100mM BBS, pH 8.2.
Concentration 0.5 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at 4 deg C.

General Information

Biological Significance CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the long arm of chromosome 11. There is no confimed ligand for CD5.

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Availability: In stock

Price: £200.31
Size: 500 ug
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