CD8 antibody (FITC) (61R-CD8cGPFT)

Mouse monoclonal CD8 antibody (FITC)

Synonyms Monoclonal CD8 antibody, Anti-CD8 antibody, CD8, CD-8 antibody, CD 8, CD 8 antibody, CD-8
Specificity Guinea Pig
Cross Reactivity To be determined by end-user
Applications FC
Immunogen CD8 antibody (FITC) was raised in mouse using guinea pig peritoneal T-Cells as the immunogen.

Images

Flow cytometric assay using CD8 antibody (FITC) (61R-CD8cGPFT)

Combination drug therapy with RZ/TMC207 significantly reduced the accumulation of activated T cells, macrophages expressing MHC class II, and neutrophils into the infected lungs. The numbers of CD4+ CD45+ (A), CD4+ CT4+ (B), CD8+ CT4+ (C), macrophage MHC class IIhi (D), and heteroneutrophil (E) cells accumulating in the lungs of untreated controls (○) and RZ/TMC207(□) treatment which began on day 20 were determined, and the effects of drug treatment measured 2, 4, and 6 weeks later in the guinea pigs were charted. The results are expressed as the average total number of cells (107) expressing the indicated phenotypes (n = 4) per 1.0 g of tissue (± SEM). Student t test: *, P < 0.050.

Specifications

Host Mouse
Clone CT6
Isotype IgG1
Method of Purification CD8 antibody (FITC) was purified by Protein A affinity chromatography.
Tag/Conjugate FITC
Form & Buffer FITC liquid presented in BSA pH7.4 containing 0.09% NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations FC: Neat

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance The CD8 molecule is composed of two chains . It is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20 to 35 percent of human peripheral blood lymphocytes. The CD8 antigen is reported to be detected on natural killer cells, 80 percent of thymocytes, on a subpopulation of 30 percent of peripheral blood null cells and 15 to 30 percent of bone marrow cells.

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Images

  • Flow cytometric assay using CD8 antibody (FITC) (61R-CD8cGPFT) | Combination drug therapy with RZ/TMC207 significantly reduced the accumulation of activated T cells, macrophages expressing MHC class II, and neutrophils into the infected lungs. The numbers of CD4+ CD45+ (A), CD4+ CT4+ (B), CD8+ CT4+ (C), macrophage MHC class IIhi (D), and heteroneutrophil (E) cells accumulating in the lungs of untreated controls (○) and RZ/TMC207(□) treatment which began on day 20 were determined, and the effects of drug treatment measured 2, 4, and 6 weeks later in the guinea pigs were charted. The results are expressed as the average total number of cells (107) expressing the indicated phenotypes (n = 4) per 1.0 g of tissue (± SEM). Student t test: *, P < 0.050.
  • Immunohistochemical staining using CD8 antibody (FITC) (61R-CD8cGPFT) | Dermal exposure to SM promotes T cell emigration into the skin. Guinea pig skin from a site exposed to air (control) (A) and 2 weeks post exposure of SM (B). Cryosections of the skin were stained for the T-lymphocyte cell-surface markers, CD4 and CD8 as detailed in Materials and Methods. Red, CD4+ cells (black arrowhead) and black, CD8+ cells (white arrowhead) are shown in periadnexal superficial dermis of control animals (grade 2 = 6 –15 cells per 40 × field) and more numerous in this focus of superficial dermis of SM-exposed animals after 2 weeks (grade 3 = 16–45 cells per 40 × field) than in most microscopic fields of control specimens. Other indicators: k, keratin; e, epidermis; f, follicle. Bar = 25 um.

Availability: In stock

Price: £460.72
Size: 100 tests
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