CDC26 protein (His tag) (80R-1851)
Purified recombinant CDC26 protein
|Synonyms||Anaphase-promoting complex subunit CDC26 protein, ANAPC12 protein, CDC-26, CDC 26 protein, APC12 protein, CDC26, CDC 26, CDC-26 protein|
Coomassie Blue stained SDS-PAGE of CDC26 protein (His tag) (80R-1851)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-85 amino acids: MGSSHHHHHH SSGLVPRGSH MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF|
|Grade & Purity||> 90% pure|
|Molecular Weight||11.9 kDa (105aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 40% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CDC26, also known as ANAPC12, APC12, belongs to the CDC26 family which orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains. This protein is component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Recombinant human CDC26 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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