CDC37 protein (30R-1205)
Purified recombinant Human CDC37 protein
|Synonyms||CDC-37, CDC 37 protein, CDC37 protein protein, p50 protein, CDC37, CDC-37 protein, Hsp90 co chaperone Cdc37 protein, Hsp90 chaperone protein kinase targeting subunit p50Cdc37 protein, CDC37 cell division cycle 37 homolog protein, P50CDC37 protein, p50Cdc37., Hsp90 chaperone protein kinase targeting subunit protein, CDC 37 protein, Cell division cycle 37 homolog protein, Cell division cycle 37 homolog S cerevisiae hypothetical protein CDC37 protein, CDC 37, Cdc37 homolog protein, CDC37 protein|
Coomassie Blue stained SDS-PAGE of CDC37 protein (30R-1205)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-378 amino acids: MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG DPLLEAVPKT GDEKDVSV|
|Grade & Purity||> 95% pure|
|Molecular Weight||44.4Da (378aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||CDC37, an essential gene in Saccharomyces cerevisiae, interacts genetically with multiple protein kinases. Cdc37 associates with the heat-shock protein 90 (Hsp90) molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. Cdc37 up-regulation is a common early event in some localized human cancers. Recombinant CDC37 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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