CERKL antibody (70R-9906)
Affinity purified rabbit polyclonal CERKL antibody
|Synonyms||Polyclonal CERKL antibody, Anti-CERKL antibody, RP26 antibody, ceramide kinase-like antibody|
|Immunogen||CERKL antibody was raised in rabbit using the C terminal of CERKL as the immunogen|
|Assay Information||CERKL Blocking Peptide, catalog no. 33R-1539, is also available for use as a blocking control in assays to test for specificity of this CERKL antibody|
Western Blot analysis using CERKL antibody (70R-9906)
CERKL antibody (70R-9906) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.|
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