Chromogranin A protein (His tag) (80R-1153)
Purified recombinant Human Chromogranin A protein
|Synonyms||Parathyroid secretory protein 1 protein, Chromogranin-A protein, Pancreastatin protein, Chromogranin A precursor protein, beta Granin protein, , CHG A protein, Vasostatin protein, SP I protein, ChromograninA protein, SP1 protein, Parastatin protein, Pituitary secretory protein I (SP1) protein, Chromogranin A parathyroid secretory protein 1 protein, Pituitary secretory protein I protein, CHGA protein, CgA protein, SPI protein|
Coomassie Blue stained SDS-PAGE of Chromogranin A protein (His tag) (80R-1153)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||19-457 amino acids: MGSSHHHHHH SSGLVPRGSH MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVMEKREDSK EAEKSGEATD GARPQALPEP MQESKAEGNN QAPGEEEEEEEEATNTHPPA SLPSQKYPGP QAEGDSEGLS QGLVDREKGL SAEPGWQAKR EEEEEEEEEA EAGEEAVPEE EGPTVVLNPH PSLGYKEIRK GESRSEALAV DGAGKPGAEE AQDPEGKGEQ EHSQQKEEEE EMAVVPQGLF RGGKSGELEQ EEERLSKEWE DSKRWSKMDQ LAKELTAEKR LEGQEEEEDN RDSSMKLSFR ARAYGFRGPG PQLRRGWRPS SREDSLEAGL PLQVRGYPEE KKEEEGSANR RPEDQELESL SAIEAELEKV AHQLQALRRG|
|Grade & Purity||> 80% pure|
|Molecular Weight||51.2 kDa (460aa)|
|Form & Buffer||20mM Tris-HCl (ph.7.5) containing 2mM EDTA, 0.1mM PMSF, 10% Glycerol|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Chromogranin A is a member of the chromogranin/secretogranin (granins) family of neuroendocrine secretory proteins. Chromogranin A (CgA) represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. It is considered a diagnostic and prognostic marker of several diseases, including a variety of tumours and cardiac heart failure. Recombinant human Chromogranin A, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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