CLIC2 protein (His tag) (80R-1777)
Purified recombinant Human CLIC2 protein
|Synonyms||CLIC 2 protein, CLIC2b protein, CLIC-2 protein, CLIC 2, XAP121 protein, CLIC2, CLIC-2, Chloride intracellular channel protein 2 protein|
Coomassie Blue stained SDS-PAGE of CLIC2 protein (His tag) (80R-1777)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-247 amino acids: MGSSHHHHHH SSGLVPRGSH MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS|
|Grade & Purity||> 95% pure|
|Molecular Weight||30.5 kDa(267aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CLIC2, also known as, chloride intracellular channel protein 2, regulates cellular traffic of chloride ions, a critical component of all living cells. This protein is involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. It is detected in fetal liver and adult skeletal muscle tissue. It is a potential candidate for one of the many diseases linked to Xq28. Recombinant human CLIC2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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