CMA1 antibody (70R-9959)
Affinity purified rabbit polyclonal CMA1 antibody
|Synonyms||Polyclonal CMA1 antibody, Anti-CMA1 antibody, chymase 1, MGC119891 antibody, chymase antibody, CMA-1 antibody, MCT1 antibody, mast cell antibody, CMA 1, MGC119890 antibody, CMA-1, CYH antibody, CMA 1 antibody, CMA1|
|Immunogen||CMA1 antibody was raised in rabbit using the C terminal of CMA1 as the immunogen|
|Assay Information||CMA1 Blocking Peptide, catalog no. 33R-2795, is also available for use as a blocking control in assays to test for specificity of this CMA1 antibody|
Western Blot analysis using CMA1 antibody (70R-9959)
CMA1 antibody (70R-9959) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.|
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