CNTFR antibody (70R-9962)
Affinity purified rabbit polyclonal CNTFR antibody
|Synonyms||Polyclonal CNTFR antibody, Anti-CNTFR antibody, ciliary neurotrophic factor receptor antibody, MGC1774 antibody|
|Immunogen||CNTFR antibody was raised in rabbit using the C terminal of CNTFR as the immunogen|
|Assay Information||CNTFR Blocking Peptide, catalog no. 33R-1094, is also available for use as a blocking control in assays to test for specificity of this CNTFR antibody|
Western Blot analysis using CNTFR antibody (70R-9962)
CNTFR antibody (70R-9962) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types.|
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