COL1A1 antibody (70R-9963)
Affinity purified rabbit polyclonal COL1A1 antibody
|Synonyms||Polyclonal COL1A1 antibody, Anti-COL1A1 antibody, COLA-1, COLA-1 antibody, alpha 1 antibody, collagen, COLA 1 antibody, type I, OI4 antibody, COL1A1, COLA 1|
|Immunogen||COL1A1 antibody was raised in rabbit using the C terminal of COL1A1 as the immunogen|
|Assay Information||COL1A1 Blocking Peptide, catalog no. 33R-3394, is also available for use as a blocking control in assays to test for specificity of this COL1A1 antibody|
Western Blot analysis using COL1A1 antibody (70R-9963)
Western Blot showing COL1A1 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.|
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