CTSC antibody (70R-9985)

Affinity purified rabbit polyclonal CTSC antibody

Synonyms Polyclonal CTSC antibody, Anti-CTSC antibody, DPPI antibody, PLS antibody, HMS antibody, PALS antibody, CPPI antibody, DPP1 antibody, cathepsin C antibody, JP antibody, JPD antibody
Cross Reactivity Human
Applications WB
Immunogen CTSC antibody was raised in rabbit using the middle region of CTSC as the immunogen
Assay Information CTSC Blocking Peptide, catalog no. 33R-10021, is also available for use as a blocking control in assays to test for specificity of this CTSC antibody

Images

Western Blot analysis using CTSC antibody (70R-9985)

Western Blot showing CTSC antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

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Images

  • Western Blot analysis using CTSC antibody (70R-9985) | Western Blot showing CTSC antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Availability: In stock

Price: £276.43
Size: 50 ug
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