CYP21A2 antibody (70R-9997)
Affinity purified rabbit polyclonal CYP21A2 antibody
|Synonyms||Polyclonal CYP21A2 antibody, Anti-CYP21A2 antibody, CPS1 antibody, CA21H antibody, cytochrome P450, polypeptide 2 antibody, CYPA2-21, CYP21B antibody, subfamily A, CYPA2 21, CYPA2 21 antibody, P450c21B antibody, CYPA2-21 antibody, CYP21A2, family 21, CAH1 antibody, MGC150537 antibody, CYP21 antibody, MGC150536 antibody|
|Immunogen||CYP21A2 antibody was raised in rabbit using the C terminal of CYP21A2 as the immunogen|
|Assay Information||CYP21A2 Blocking Peptide, catalog no. 33R-4122, is also available for use as a blocking control in assays to test for specificity of this CYP21A2 antibody|
Western Blot analysis using CYP21A2 antibody (70R-9997)
Western Blot showing CYP21A2 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.|
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