CYP2A6 antibody (70R-9991)
Affinity purified rabbit polyclonal CYP2A6 antibody
|Synonyms||Polyclonal CYP2A6 antibody, Anti-CYP2A6 antibody, CYP2A3 antibody, P450C2A antibody, P450PB antibody, subfamily A, CYP2A antibody, polypeptide 6 antibody, CYPA6-2 antibody, cytochrome P450, family 2, CYPA6 2, CYPA6-2, CYP2A6, CYPA6 2 antibody, CPA6 antibody|
|Immunogen||CYP2A6 antibody was raised in rabbit using the C terminal of CYP2A6 as the immunogen|
|Assay Information||CYP2A6 Blocking Peptide, catalog no. 33R-1182, is also available for use as a blocking control in assays to test for specificity of this CYP2A6 antibody|
Western Blot analysis using CYP2A6 antibody (70R-9991)
Western Blot showing CYP2A6 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CYP2A6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.|
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