CYP3A5 antibody (70R-9993)
Affinity purified rabbit polyclonal CYP3A5 antibody
|Synonyms||Polyclonal CYP3A5 antibody, Anti-CYP3A5 antibody, PCN3 antibody, CYPA5-3 antibody, P450PCN3 antibody, CYPA5-3, cytochrome P450, polypeptide 5 antibody, family 3, CYPA5 3 antibody, CYPA5 3, CP35 antibody, CYP3A5, subfamily A|
|Immunogen||CYP3A5 antibody was raised in rabbit using the N terminal of CYP3A5 as the immunogen|
|Assay Information||CYP3A5 Blocking Peptide, catalog no. 33R-1283, is also available for use as a blocking control in assays to test for specificity of this CYP3A5 antibody|
Western Blot analysis using CYP3A5 antibody (70R-9993)
Western Blot showing CYP3A5 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.|
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