DDB2 antibody (70R-10002)
Affinity purified rabbit polyclonal DDB2 antibody
|Synonyms||Polyclonal DDB2 antibody, Anti-DDB2 antibody, damage-specific DNA binding protein 2, UV-DDB2 antibody, DDB-2, DDB 2 antibody, DDB 2, 48kDa antibody, FLJ34321 antibody, DDB-2 antibody, DDB2, DDBB antibody|
|Immunogen||DDB2 antibody was raised in rabbit using the C terminal of DDB2 as the immunogen|
|Assay Information||DDB2 Blocking Peptide, catalog no. 33R-4210, is also available for use as a blocking control in assays to test for specificity of this DDB2 antibody|
Western Blot analysis using DDB2 antibody (70R-10002)
Western Blot showing DDB2 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.|
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