DSCR1 isoform b protein (30R-1111)
Purified recombinant Human DSCR1 isoform b protein
|Synonyms||DSCR1, Down syndrome candidate region 1, calcipressin 1 protein, DSCR 1, DSCR 1 protein, Down syndrome candidate region 1 protein, DSCR-1, Calcipressin 1 isoform b protein, adapt78 protein protein, Down syndrome critical region protein 1 protein, DSCR-1 protein|
Coomassie Blue stained SDS-PAGE of DSCR1 isoform b protein (30R-1111)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-117 amino acids: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS|
|Grade & Purity||> 90% pure|
|Molecular Weight||13 kDa (117aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 7.5, containing 0.1M NaCl, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.|
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