Epiregulin protein (30R-AE017)

Purified recombinant Human Epiregulin protein

Synonyms EREG protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Epiregulin protein corresponding to amino acids MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 5.6 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is approximately 2.0 ng/ml, corresponding to a specific activity of approximately 5 x 10^5units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

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Availability: In stock

Price: £180.28
Size: 25 ug
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