F11 antibody (70R-10231)

Affinity purified rabbit polyclonal F11 antibody

Synonyms Polyclonal F11 antibody, Anti-F11 antibody, FXI antibody, F 11, F-11 antibody, MGC141891 antibody, F-11, F11, coagulation factor XI antibody, F 11 antibody
Cross Reactivity Human
Applications WB
Immunogen F11 antibody was raised in rabbit using the C terminal of F11 as the immunogen
Assay Information F11 Blocking Peptide, catalog no. 33R-7950, is also available for use as a blocking control in assays to test for specificity of this F11 antibody

Images

Western Blot analysis using F11 antibody (70R-10231)

Western Blot showing F11 antibody used at a concentration of 1 ug/ml against Hela Cell Lysate

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

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Images

  • Western Blot analysis using F11 antibody (70R-10231) | Western Blot showing F11 antibody used at a concentration of 1 ug/ml against Hela Cell Lysate

Availability: In stock

Price: £276.43
Size: 50 ug
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