F7 antibody (70R-9969)
Affinity purified rabbit polyclonal F7 antibody
|Synonyms||Polyclonal F7 antibody, Anti-F7 antibody, F-7, coagulation factor VII, F7, serum prothrombin conversion accelerator antibody, F 7, F 7 antibody, F-7 antibody|
|Immunogen||F7 antibody was raised in rabbit using the C terminal of F7 as the immunogen|
|Assay Information||F7 Blocking Peptide, catalog no. 33R-1026, is also available for use as a blocking control in assays to test for specificity of this F7 antibody|
Western Blot analysis using F7 antibody (70R-9969)
F7 antibody (70R-9969) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.|
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