F8 antibody (70R-9971)

Affinity purified rabbit polyclonal F8 antibody

Synonyms Polyclonal F8 antibody, Anti-F8 antibody, F 8 antibody, coagulation factor VIII, procoagulant component antibody, FVIII antibody, F-8, F-8 antibody, AHF antibody, F 8, HEMA antibody, F8B antibody, F8C antibody, DXS1253E antibody, F8
Cross Reactivity Human
Applications WB
Immunogen F8 antibody was raised in rabbit using the C terminal of F8 as the immunogen
Assay Information F8 Blocking Peptide, catalog no. 33R-3569, is also available for use as a blocking control in assays to test for specificity of this F8 antibody

Images

Western Blot analysis using F8 antibody (70R-9971)

Western Blot showing F8 antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

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Images

  • Western Blot analysis using F8 antibody (70R-9971) | Western Blot showing F8 antibody used at a concentration of 1-2 ug/ml to detect its target protein.

Availability: In stock

Price: £300.47
Size: 50 ug
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