F8 antibody (70R-9971)
Affinity purified rabbit polyclonal F8 antibody
|Synonyms||Polyclonal F8 antibody, Anti-F8 antibody, F 8 antibody, coagulation factor VIII, procoagulant component antibody, FVIII antibody, F-8, F-8 antibody, AHF antibody, F 8, HEMA antibody, F8B antibody, F8C antibody, DXS1253E antibody, F8|
|Immunogen||F8 antibody was raised in rabbit using the C terminal of F8 as the immunogen|
|Assay Information||F8 Blocking Peptide, catalog no. 33R-3569, is also available for use as a blocking control in assays to test for specificity of this F8 antibody|
Western Blot analysis using F8 antibody (70R-9971)
Western Blot showing F8 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.|
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