FHIT protein (His tag) (80R-1327)

Purified recombinant Human FHIT protein

Synonyms Fragile histidine triad protein protein, Bis (5'-adenosyl)-triphosphatase protein, FRA3B protein, FRA 3B protein, Fragile histidine triad gene protein, AP3A hydrolase fragile site 3p14.2 protein, Bis 5' adenosyl triphosphatase protein, Fragile histidine triad protein, Tumor suppressor protein., Fragile histidine triad protein AP3A hydrolase protein, Diadenosine 5' 5''' P1 P3 triphosphate hydrolase protein, Dinucleosidetriphosphatase protein, AP3Aase protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of FHIT protein (His tag) (80R-1327)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-147 amino acids: MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQLEH HHHHH
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 17.9 kDa(155aa), confirmed by MALDI-TOF
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance FHIT (fragile histidine triad) is an enzyme that cleaves adenosine 5' PPP 5' A to yield AMP and ADP. FHIT gene encompasses the common fragile site FRA3B on chromosome 3. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. This protein physically associates with ubiquitin conjugating enzyme 9. Recombinant human FHIT, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.

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Images

  • Coomassie Blue stained SDS-PAGE of FHIT protein (His tag) (80R-1327) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: £176.28
Size: 100 ug
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