GADD153 protein (His tag) (80R-1068)
Purified recombinant Human GADD153 protein
|Synonyms||Growth Arrest and DNA Damage Inducible Protein 153 protein, DDIT 3 protein, CHOP10 protein, GADD 153 protein, CEBPZ protein, GADD 153, Growth arrest-and DNA damage-inducible gene 153 C/EBP homologous protein protein, GADD-153, , CHOP 10 protein, GADD-153 protein, DDIT3 protein, C/EBP Homology Protein protein, Growth arrest-and DNA damage-inducible gene 153 protein, DNA Damage Inducible Transcript 3 protein, GADD153 protein, GADD153, MGC4154 protein, GADD 153 protein, CHOP protein|
Coomassie Blue stained SDS-PAGE of GADD153 protein (His tag) (80R-1068)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-169 amino acids: MGSSHHHHHH SSGLVPRGSH MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA|
|Grade & Purity||> 90% pure|
|Molecular Weight||21.3 kDa (189aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GADD153, also known as DNA-damage-inducible transcript 3 (DDIT3), is a basic domain-leucine zipper(bZIP) transcription factor of C/EBP family. This protein has been shown to be up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum (ER) stress, osmotic stress and hypoxia. GADD153 protein may play a role in ER stress-mediated apoptosis and in disease including diabetes, brain ischemia and neurodegenerative disease. Recombinant GADD153 fused with His-tag, was expressed in E. coli and purified by conventional chromatography techniques.|
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