GADD45A protein (His tag) (80R-1312)
Purified recombinant Human GADD45A protein
|Synonyms||GADDA-45, GADDA-45 protein, , DNA damage inducible transcript 1 protein, Growth arrest and DNA damage inducible 45 alpha protein, GADDA 45 protein, DDIT1 protein, GADD45 protein, GADD45A, Growth arrest and DNA damage-inducible protein GADD45 alpha DDIT 1 protein, GADDA 45|
Coomassie Blue stained SDS-PAGE of GADD45A protein (His tag) (80R-1312)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-165 amino acids: MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPERLEHHH HHH|
|Grade & Purity||> 85% pure|
|Molecular Weight||19.4 kDa (173aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GADD45A, also known as growth arrest and DNA damage-inducible protein, binds both Cdks and PCNA, a protein involved in DNA replication and repair. It has been shown to stimulate DNA excision repair in vitro and to inhibit entry of cells into S phase. This protein may serve as a link between p53-dependent cell cycle checkpoint and DNA repair. Recombinant human GADD45A protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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