GDNF antibody (70R-GR020)

Affinity purified Rabbit polyclonal GDNF antibody

Synonyms Polyclonal GDNF antibody, Anti-GDNF antibody, Glial-Derived Neurotrophic Factor antibody, ATF-1 antibody
Specificity Human GDNF
Cross Reactivity To be determined by end-user
Applications ELISA, Inhibition, WB
Immunogen GDNF antibody was raised in rabbit using highly pure recombinant human GDNF as the immunogen.

Specifications

Host Rabbit
Form & Buffer Lyophilized from PBS, pH 7.2.

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR a(a1-a4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson?s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.

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Availability: In stock

Price: £180.28
Size: 50 ug
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