GDNF protein (30R-AG038)

Purified recombinant Human GDNF protein

Synonyms Glial-Derived Neurotrophic Factor protein, ATF-1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of GDNF protein corresponding to amino acids MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI.
Expression System E.coli
Grade & Purity > 98% pure
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined by the proliferation of rat C6 cells is approximately 0.2 ng/ml, corresponding to a specific activity of approximately 5 x 10^6 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR a(a1-a4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson?s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.

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Availability: In stock

Price: £180.28
Size: 10 ug
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