Geminin protein (His tag) (80R-1016)
Purified recombinant Human Geminin protein
|Synonyms||Geminin protein, Geminin protein, Gem protein, DNA replication inhibitor protein, Geminin DNA replication inhibitor protein, GMNN protein, OTTHUMP00000039393 protein, RP3 369A17.3.|
Coomassie Blue stained SDS-PAGE of Geminin protein (His tag) (80R-1016)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNPS MKQKQEEIKE NIKNSSVPRR TLKMIQPSAS GSLVGRENEL SAGLSKRKHR NDHLTSTTSS PGVIVPESSE NKNLGGVTQE SFDLMIKENP SSQYWKEVAE KRRKALYEAL KENEKLHKEI EQKDNEIARL KKENKELAEV AEHVQYMAEL IERLNGEPLD NFESLDNQEF DSEEETVEDS LVEDSEIGTC AEGTVSSSTD AKPCI|
|Grade & Purity||> 95% pure|
|Molecular Weight||27.6 kDa (245aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 100mM NaCl, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Geminin is a 25 kDa protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions.|
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