Glutaredoxin 1 protein (30R-1244)
Purified recombinant Human Glutaredoxin 1 protein
|Synonyms||TTase-1 protein, Glutaredoxin protein, GLRX protein, TTase 1 protein, Glutaredoxin-1, Glutaredoxin 1, Glutaredoxin 1 protein, Ttase protein, GRX protein, GRX1 protein, MGC117407 protein, Glutaredoxin1, Grx 1 protein, Thioltransferase protein, Glrx1 protein, Thioltransferase 1 protein, Glutaredoxin-1 protein, Thioltransferase-1 protein, Thioltransferase1 protein, TTase1., Glutaredoxin1 protein|
Coomassie Blue stained SDS-PAGE of Glutaredoxin 1 protein (30R-1244)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-106 amino acids: MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ|
|Grade & Purity||> 95% pure|
|Molecular Weight||11.7 kDa (106 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Glutaredoxin(GRX), also known as thioltransferase, is a member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Mammalian Glutaredoxin is known to have two isoforms, GRX1 and GRX2. GRX1 is a cytosolic protein, whereas GRX2 is localized both in the mitochondria and nucleus. Glutaredoxin-1 may be involved in a various cellular events such as signal transduction, stress response, and metabolic regulation by regulating the redox status of cellular proteins. Recombinant human Glutaredoxin1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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