HDGF protein (30R-1402)
Purified recombinant Human HDGF protein
|Synonyms||HMG1L2 protein, , High mobility group protein 1 like 2 protein, Hepatoma-derived growth factor isoform a Hepatoma derived growth factor protein|
Coomassie Blue stained SDS-PAGE of HDGF protein (30R-1402)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-100 amino acids: MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY|
|Grade & Purity||> 95% pure|
|Molecular Weight||11.5 kDa (100aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1mM DTT, 10% glycerol, and 1mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Hepatoma-derived growth factor isoform a, also known as HDGF, belongs to the hepatoma-derived growth factor family. HDGF was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. This nuclear targeted vascular smooth muscle cell mitogen is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. Recombinant human HDGF was expressed in E. coli and purified by using conventional chromatography techniques.|
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