Hexokinase 4 protein (His tag) (80R-1022)
Purified recombinant Human Hexokinase 4 protein
|Synonyms||Glucokinase protein, HK 4 protein, Hexokinase D pancreatic isozyme protein, Hexokinase Type 4, Hexokinase Type 4 protein, MODY2., Hexokinase-4 protein, Hexokinase D protein, Hexokinase 4 protein, Hexokinase 4 protein, HK IV protein, HK4 protein, EC 22.214.171.124 protein, HexokinaseD protein, GK protein, ATP D hexose 6 phosphotransferase protein, HHF 3 protein, HHF3 protein, Hexokinase4 protein, Hexokinase-D protein, GLK protein, Maturity onset diabetes of the young 2 protein, GCK protein, Hexokinase Type -4, Hexokinase type IV protein, Hexokinase Type -4 protein, MODY 2 protein, Glucokinase protein, HXKP protein, Glucokinase isoform 1 protein, Hexokinase Type 4|
Coomassie Blue stained SDS-PAGE of Hexokinase 4 protein (His tag) (80R-1022)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MGSSHHHHHH SSGLVPRGSH MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ|
|Grade & Purity||> 95% pure|
|Molecular Weight||54.3 kDa (485aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase 4 is found in the liver and pancreatic beta-cells, where it is controlled by insulin (activation) and glucagon (inhibition). In pancreatic beta-cells, type IV enzyme acts as a glucose sensor to modify insulin secretion. Hexokinase4 is commonly called ?glucokinase?. Recombinant human Hexokinase4, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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