HSPB8/HSP22 protein (His tag) (80R-1266)
Purified recombinant Human HSPB8/HSP22 protein
|Synonyms||HMN2A protein, HSPB8/HSP22, H11 protein, DHMN2 protein, HSPB/HSP22-8, HSPB/HSP22 8 protein, CMT2L protein, heat shock 22kDa protein 8 protein, CRYAC protein, Heat shock protein beta-8 protein, HSP22 protein, HSPB/HSP22-8 protein, E2IG1 protein, HspB8, HMN2 protein, HSPB/HSP22 8|
Coomassie Blue stained SDS-PAGE of HSPB8/HSP22 protein (His tag) (80R-1266)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-196 amino acids: MGSSHHHHHH SSGLVPRGSH MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT|
|Grade & Purity||> 95% pure|
|Molecular Weight||23.7 kDa (216aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 100mM NaCl and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Heat shock protein beta-8 (HSPB8), also known as HSP22, is a member of the small heat shock protein superfamily. HSPB8 is predominantly transcribed in skeletal muscle and heart. The chaperone-like activity is of great importance to the function of HSPB8 in various processes including proliferation, apoptosis and macroautophagy. Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L). Recombinant human HSPB8, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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