IGF1 protein (30-AI88)

Purified recombinant Human IGF1 protein

Synonyms IGF 1 protein, IGF 1, IGF-1 protein, IGF1, Insulin-like Growth Factor-1 protein, IGF-1A protein, Somatamedin C protein, IGF-1
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IGF1 protein corresponding to amino acids GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA.
Expression System E.coli
Grade & Purity > 98% pure
Form & Buffer Lyophilized with no additives. DO NOT VORTEX. Reconstitute in laboratory grade water to a concentration of 0.1 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 was determined by a cell proliferation assay using FDC-P1 cells is 2.0 ng/ml, corresponding to a specific activity of 5 x 10^5 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.

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Availability: In stock

Price: £220.34
Size: 100 ug
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