IL1 beta protein (30R-AI071)

Purified recombinant Human IL1 beta protein

Synonyms IL 1 protein, EP protein, IL-1 protein, MCF protein, IL1, LAF protein, Leukocyte Endogenous Mediator protein, IL-1 beta protein, Interleukin 1 beta protein, Endogenous Pyrogen protein, IL 1, Mononuclear Cell Factor protein, Catabolin protein, Lymphocyte-activating factor protein, IL-1, LEM protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL1 beta protein corresponding to amino acids MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 17.3 kDa
Form & Buffer Lyophilized from 10mM NaC2H3O2, pH 6.5. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. When dissolved, dilute further into aqueous buffered solutions.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of Mouse D10S cells is 1 x 10^7 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.

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Availability: In stock

Price: £180.28
Size: 10 ug
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